Charles A Thornton Selected Research

Myotonia

1/2021	Targeted splice sequencing reveals RNA toxicity and therapeutic response in myotonic dystrophy.
11/2013	Reducing levels of toxic RNA with small molecules.
7/2012	From dynamic combinatorial 'hit' to lead: in vitro and in vivo activity of compounds targeting the pathogenic RNAs that cause myotonic dystrophy.
12/2010	Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle.
2/2010	Evoked myotonia can be "dialed-up" by increasing stimulus train length in myotonic dystrophy type 1.
4/2009	Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy.
12/2007	Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy.
1/2007	Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy.
8/2006	Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy.
12/2004	Truncated ClC-1 mRNA in myotonic dystrophy exerts a dominant-negative effect on the Cl current.

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Charles A Thornton Research Topics

Disease

49	Myotonic Dystrophy (Dystrophia Myotonica) 01/2021 - 07/2002
12	Myotonia 01/2021 - 07/2002
8	Muscular Dystrophies (Muscular Dystrophy) 01/2021 - 01/2008
5	Inborn Genetic Diseases (Disease, Hereditary) 01/2018 - 10/2002
3	Huntington Disease (Huntington's Disease) 10/2018 - 03/2007
3	Channelopathies 12/2007 - 07/2002
2	Muscle Weakness 06/2017 - 03/2012
1	Neoplasms (Cancer) 10/2022
1	Chronic Disease (Chronic Diseases) 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2018
1	Body Weight (Weight, Body) 06/2017
1	Muscular Diseases (Myopathy) 10/2016
1	Rare Diseases (Rare Disease) 03/2012
1	Oculopharyngeal Muscular Dystrophy 01/2012
1	Hypoglycemia (Reactive Hypoglycemia) 01/2011
1	Papilledema 01/2011
1	Dizziness (Lightheadedness) 01/2011
1	Hypertrophy 10/2009
1	Muscular Atrophy (Muscle Atrophy) 10/2009
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 07/2009
1	Cardiac Conduction System Disease 01/2008
1	Heart Diseases (Heart Disease) 11/2005
1	Myasthenia Gravis 10/2002

Drug/Important Bio-Agent (IBA)

32	RNA (Ribonucleic Acid)IBA 01/2021 - 07/2002
10	Proteins (Proteins, Gene)FDA Link 09/2016 - 12/2004
7	3' Untranslated Regions (3' UTR)IBA 01/2020 - 10/2003
5	Protein Kinases (Protein Kinase)IBA 01/2020 - 03/2012
5	Messenger RNA (mRNA)IBA 01/2020 - 12/2004
5	Myotonin-Protein KinaseIBA 10/2016 - 01/2007
5	RNA Precursors (Precursor, mRNA)IBA 01/2013 - 07/2002
5	Chloride Channels (Chloride Channel)IBA 04/2009 - 07/2002
5	ChloridesIBA 12/2007 - 07/2002
4	Antisense OligonucleotidesIBA 01/2021 - 07/2009
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 12/2013
4	LigandsIBA 10/2018 - 07/2009
3	RNA Splicing FactorsIBA 01/2021 - 07/2012
3	Carrier Proteins (Binding Protein)IBA 01/2012 - 10/2006
2	Nucleic AcidsIBA 10/2018 - 03/2015
2	Pentamidine (NebuPent)FDA LinkGeneric 11/2013 - 11/2009
2	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 02/2010
2	Nuclear RNAIBA 08/2012 - 11/2005
2	NucleotidesIBA 12/2009 - 12/2009
1	ISIS 486178IBA 06/2017
1	AminoglycosidesIBA 12/2012
1	MicroRNAs (MicroRNA)IBA 03/2012
1	Calcium Channels (Calcium Channel)IBA 03/2012
1	polyalanineIBA 01/2012
1	EnzymesIBA 04/2011
1	Testosterone (Sustanon)FDA Link 01/2011
1	Insulin-Like PeptidesIBA 01/2011
1	Triglycerides (Triacylglycerol)IBA 01/2011
1	Hemoglobin AIBA 01/2011
1	Insulin-Like Growth Factor Binding Protein 3IBA 01/2011
1	Green Fluorescent ProteinsIBA 12/2010
1	Pharmaceutical PreparationsIBA 02/2010
1	p38 Mitogen-Activated Protein KinasesIBA 10/2009
1	MyostatinIBA 10/2009
1	OligonucleotidesIBA 08/2009
1	MorpholinosIBA 07/2009
1	Gap Junction alpha-5 ProteinIBA 01/2008
1	Connexin 43 (Connexin43)IBA 01/2008
1	Transcription Factors (Transcription Factor)IBA 01/2008
1	IonsIBA 12/2007
1	Muscle Proteins (Muscle Protein)IBA 10/2007
1	junctophilinIBA 03/2007
1	CLC-1 channelIBA 01/2007
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 11/2005
1	Intravenous Immunoglobulins (IVIG)FDA Link 10/2002
1	Sodium Channels (Sodium Channel)IBA 10/2002
1	A-Form DNA (A-DNA)IBA 10/2002

Therapy/Procedure

3	Therapeutics 06/2017 - 04/2015
1	Braces 10/2022
1	Walkers 10/2022
1	Canes (Cane) 10/2022
1	Investigational Therapies (Experimental Therapy) 03/2012